ABSTRACT
Essential tremor (ET) is a common movement disorder. It is characterized by a distinctive 4-12 Hz action tremor typically affecting bilateral upper limbs. Existing drugs for ET mainly include β-blockers, anticonvulsants, benzodiazepines, etc. However, the efficacy of existing drugs is limited. With the development of the medical research, some progress has been made in the treatment of ET. The review will explore the recent advances in the treatment of ET,such as new drugs, surgical treatment, repetitive transcranial magnetic stimulation, rehabilitation treatment, etc., in order to provide clinical application prospects.
ABSTRACT
Essential tremor(ET)is one of the most common movement disorders, with a prevalence of 4.6% in people over 65 years old.Action tremor of both upper limbs at 4-12 Hz action tremor in both upper limbs is the main clinical feature of ET patients.ET was previously considered to be a benign isolated symptomatic disease, but in recent years, researches have found that ET is a family of diseases with high clinical and genetic heterogeneities.In addition to tremor, it can also be accompanied by soft neurological signs and various non-motor symptoms, leading to different degrees of function impairment in patients.Early comprehensive evaluation and long-term follow-up of patients with ET are essential.The standardized scale is the most important tool for ET assessment.This article reviews various tremor assessment scales.
ABSTRACT
OBJECTIVES@#Idiopathic intracranial hypertension (IIH) is a syndrome that excludes secondary causes such as intracranial space-occupying lesion, hydrocephalus, cerebrovascular disease, and hypoxic ischemic encephalopathy. If not be treated promptly and effectively, IIH can cause severe, permanent vision disability and intractable, disabling headache. This study aims to explore the clinical and image features for IIH, to help clinicians to understand this disease, increase the diagnose rate, and improve the outcomes of patients.@*METHODS@#We retrospectively analyzed 15 cases of IIH that were admitted to Xiangya Hospital, Central South University, during January 2015 to September 2020. The diagnosis of IIH was based on the updated modified Dandy criteria. We analyzed clinical data of patients and did statistical analysis, including age, gender, height, weight, medical history, physical examination, auxiliary examination, treatment and outcome.@*RESULTS@#There were 10 females and 5 males. Female patients were 22 to 42 years old with median age of 39.5. Male patients were 27 to 52 years old with the median age of 44.0. The BMI was 24.14-34.17 (28.71±2.97) kg/m@*CONCLUSIONS@#IIH primarily affects women of childbearing age who are overweight. The major hazard of IIH is the severe and permanent visual loss. Typical image signs have high specificity in IIH diagnosis. Prompt diagnosis and effective treatment are significantly important to improve the outcomes of patients.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Anemia, Iron-Deficiency , Intracranial Hypertension , Pseudotumor Cerebri/diagnostic imaging , Retrospective Studies , Ventriculoperitoneal ShuntABSTRACT
Objective To test the reliability and validity of the Chinese version of State Behavioral Scale for Mechanically Ventilated Children (SBS). Methods The English version of SBS was revised and translated into Chinese version. The reliability and validity of the Chinese version of SBS was tested in 172 mechanically ventilated children. Results The Cronbach α coefficient of the Chinese SBS was 0.986. The item-level content validity index of Chinese SBS were 0.83-0.10, and the scale- level content validity index of Chinese SBS was 0.932. The correlation coefficient between the score of Chinese SBS and the Comfort Scale (CS) was 0.919 (P<0.01). Conclusions The Chinese version of SBS has been proved to be reliable and valid.It can be used to sedation assessment for mechanically ventilated children.
ABSTRACT
Objective: To prepare dexketoprofen trometamol hydrogel patches, optimize the formula and evaluate in vitro transdermal properties.Methods: Dexketoprofen trometamol hydrogel patches were prepared with NP-800 as the hydrogel patch carrier, aluminum hydrochloride as the crosslinking agent, EDTA as the crosslinking modifier and glycerol as the moisturizing agent.The formula was screened by orthogonal design with the initial viscosity, holding force, peel strength and 12 h cumulative transdermal quantity as the evaluation indices to screen out the best formula.The transdermal absorption test was carried out with an improved Franz diffusion cells to compare the enhancement of Aznoe, oleic acid and menthanol on dexketoprofen trometamol hydrogel patches.Results: The best formula was as follows: the mass percentage of NP-800, glycerol, glycerol and EDTA was 5%, 0.3% , 25% and 0.15% , respectively.The transdermal enhancers had transdermal enhancement on dexketoprofen trometamol, and among them, 3% Azone had the most significant enhancement with the enhancing rate of 3.26.Conclusion: The preparation and formula of dextroxyprofen trometamol hydrogel patches are stable, reasonable and feasible.
ABSTRACT
Objective To understand hand hygiene(HH) compliance among health care workers(HCWs) and incidence of healthcare-associated infection(HAI) in surgical patients before and after the intervention, analyze the effect of HH on cost-effectiveness of HAI.Methods From December 2012-June 2014, 78 HCWs in the department of neurosurgery of a hospital were as the intervention objects of HH compliance, 325 patients who underwent craniocerebral clean operation were as the surveyed objects, HH compliance among HCWs, incidence of HAI in surgical patients, cost of HH, and hospitalization expense before and after intervention were compared respectively.Results HH compliance among HCWs before and after intervention were 35.24% (216/613) and 73.75%(486/659)respectively (X2=180.091,P<0.001);incidence of HAI in surgical patients before and after intervention were 31.85%(50/157)and 18.45%(31/168)respectively(X2=7.782,P<0.001).Hospitalization expense before and after intervention were (89 524.90±38 856.70)￥ and (61 401.00±29 237.80)￥ respectively;average length of hospital stay before and after intervention were 36.70 days and 26.90 days respectively(t=3.296, 3.511,respectively, both P<0.01).Conclusion Improving HH compliance among HCWs can reduce the incidence of HAI and hospitalization cost, and shorten the average length of hospital stay of patients.
ABSTRACT
Objective To analyze the performance of the combination of "Countywide Medical Community" combine with "Capitation Prepayment". Methods We collected the new rural cooperative medical system ( NRCMS ) data of Funan county ( with "Countywide Medical Community" introduced in 2015, along with Capitation Payment) and Yingshang county (without"Countywide Medical Community"), both in Anhui province, from 2014 -2016. With such data, a longitudinal comparison was made on the performance of Funan "Countywide Medical Community" before and after, and a horizontal comparison on Funan county and Yingshang county regarding the merits and weakness of the Community. Results 2014-2016 witnessed a year-by-year decline of the outside-county proportion of the expenditure, man-time of inpatients, hospitalization expenses and hospitalization reimbursement by NRCMS in Funan county, and an increase of such proportion within the county. Furthermore, these proportions of Funan county were better than those of Yingshang county, proving "Countywide Medical Community" a success. Conclusions The performance of the combination of "Countywide Medical Community" and "Capitation Payment" proved a success.
ABSTRACT
Objective To analyze the performance of the combination of "Countywide Medical Community" combine with "Capitation Prepayment". Methods We collected the new rural cooperative medical system ( NRCMS ) data of Funan county ( with "Countywide Medical Community" introduced in 2015, along with Capitation Payment) and Yingshang county (without"Countywide Medical Community"), both in Anhui province, from 2014 -2016. With such data, a longitudinal comparison was made on the performance of Funan "Countywide Medical Community" before and after, and a horizontal comparison on Funan county and Yingshang county regarding the merits and weakness of the Community. Results 2014-2016 witnessed a year-by-year decline of the outside-county proportion of the expenditure, man-time of inpatients, hospitalization expenses and hospitalization reimbursement by NRCMS in Funan county, and an increase of such proportion within the county. Furthermore, these proportions of Funan county were better than those of Yingshang county, proving "Countywide Medical Community" a success. Conclusions The performance of the combination of "Countywide Medical Community" and "Capitation Payment" proved a success.
ABSTRACT
Objective To investigate the status of professional identity and its influencing factors for nursing master specialist, and explore scientific strategies to plan the career for them. Methods From October 2014 to February 2015, totally 110 nursing master specialist in 12 universities from Shanghai, Beijing, Jiangsu, Zhejiang and Shanxi provinces were tested by the Professional Identity Scale of Nursing Students. Results The average score of nursing master specialist′s professional identity was (3.46±0.53) points, and the highest score was social modeling scored 4.01±0.91and social comparison and self-reflection scored 3.68 ± 0.59, the lowest score was independence of career choice scored 3.08 ± 0.61. Multiple linear regression analysis showed that interest in the nursing profession, first record of formal schooling and grade were the influencing factors of nursing master specialist′s professional identity, three factors could explain 43.1%. Conclusions Nursing master specialist′s professional identity needs to be further improved, nursing educators and managers should take effective measures, improve nursing professional identity of master of nursing specialist students from the individual level and organizational level, promote the development of professional career.
ABSTRACT
Objective:To establish an HPLC method for the determination of chlorogenic acid in honeysuckle stem and honeysuck-le from different sources in different harvest periods. Methods:A Waters C18 column(250 mm × 4. 6 mm,5 μm)was used. The mo-bile phase consisted of acetonitrile-0. 4% H3 PO4(10:90)with the flow rate of 1. 0 ml·min-1 . The detection wavelength was 327 nm and the column temperature was 30℃. An external standard method was established for the determination of chlorogenic acid in honey-suckle stem and honeysuckle in six different harvest periods from three sources. Results:There was a good linear relationship within the range of 0. 065-1. 300 μg for chlorogenic acid(r=0. 999 8). The content of chlorogenic acid in honeysuckle was the highest in Sep-tember and October. The content of chlorogenic acid in Lonicera acuminata was the highest among the honeysuckle stem from three dif-ferent sources. Conclusion:The content of chlorogenic acid in honeysuckle has a certain relationship with the harvest time,which can provide theoretical basis for the choice of harvest time for honeysuckle stem.
ABSTRACT
Objective To investigate the perioperative nursing demands of elderly patients receiving laparoscopic cholecystectomy ( LC) . Methods A total of 195 elderly patients receiving LC were interviewed .The nursing care demands at admission, preoperation, postoperation, and discharge were collected respectively . Results On the day of admission, all the 195 patients (100%) wished to be aware of their surgeons , 191 patients ( 97.9%) wished to understand causes of disease and its prevention, 189 patients (96.9%) were willing to know the operation costs , and 124 patients (63.6%) wanted to know the influences of basic diseases on operation.During preoperative periods, 194 patients (98.5%) expected to understand the safety and time of operation, 187 patients (95.9%) were interested in the preparedness before operation , and 135 patients (69.2%) wanted to know about the strategy for treating operation stress .During postoperative periods , 195 patients ( 100%) wanted to know the operation process and outcomes , 185 patients ( 94.9%) wanted necessary cares from nurses , 172 patients ( 88.2%) wanted to know the management for postoperative pain , 148 patients ( 75.9%) expected to understand the drug prescription after operation , and 146 patients (74.9%) were interested in diets and physical activities .At the time of discharge, 195 patients (100%) wanted to be aware of reexamination time and follow-up context, 193 patients (99.0%) wanted to know dietary recommendation , and 177 patients (90.8%) were willing to know the exercise options and time . Conclusion Nurses should be aware of the perioperative care demands in elderly patients receiving LC and provide specific care services to reduce complications and improve rehabilitation .
ABSTRACT
Objective To establish HPCE method for determining the mangiferin in Baihe Zhimu decoction.Methods Rutin was used as internal standard.An uncoated fused silica capillary (77 cm×75 μm,effective length of 70 cm) was served as separation gate.The electrolyte buffer was composed of 12 mmol/L borax-MeOH (90 ∶ 10).20 kV voltages were applied and detection wavelength was set at 318nm.Results Mangiferin was successfully separated within 20 rin,the linear response range was 0.06～1.14 mg/ml.The average recovery was 99.0％.Conclusion The method was simple,rapid and well reproducible.It could be used as a reliable tool for the quantity control of Baihe Zhimu decoction and descriptions containing mangiferin.
ABSTRACT
OBJECTIVE:To study the long-term toxicity of Reketing granules.METHODS:The experiment was performed in 4 groups:one control group(normal saline)and three Reketing subgroups(188 g?kg-1,94 g?kg-1,18 g?kg-1).After intragastrical administration for 3 consecutive months,the blood routine,urine routine and serum biochemical indicators were measured in rats,and the autopsy of the major organs was performed.After drug withdrawal for 2 weeks,the above indexes were measured again to find out the abnormality.RESULTS:After 3-month medication,the rats experienced a gradual increase in body weight and developed well.In Reketing high dose-treated group,glutamate-pyruvate transaminase(GPT)and blood urea nitrogen(BUN)levels increased slightly;and except for lesion of liver and kidney in small number of rats,the peripheral hemogram,urine routine and the blood biochemical indicators were all normal.The above indexes and the pathological findings of the organs after drug withdrawal for 2 weeks were all normal.CONCLUSION:Reketing granules can lead to mild lesion of liver and kidney of rats during medication,but the symptoms disappear after drug withdrawal.
ABSTRACT
OBJECTIVE:To explore an effective mode and way for the reduction of drug repercussion in dispensary. METHODS: Based on the statistics on drug repercussion data in 2005 and the analysis on the causes of drug repercussion, the Drug Repercussion Administrative Policy of Hospital (which was called Policy for short in the following) was set and enforced. RESULTS: A year-on-year sharp decrease in the numbers of prescriptions (both inpatient and outpatient) involving drug repercussion has been noted after implementing Policy in our hospital(P
ABSTRACT
AIM:To observe the expression of calcium-sensing receptor(CaSR) of rat cardiomyocytes in anoxia-reoxygenation(A/R) injury and CaSR-induced changes of intracellular calcium;involvement of CaSR in apoptosis and relevant signaling transduction pathway.METHODS:The A/R injury was remodeled in vitro;CaSR,caspase 3 and caspase 9 were deteced by Western blotting.LSCM was used to observe changes of intracellular calcium during reperfusion with or without CaSR agonist.Morphological changes in different groups were observed by light microscopes.Apoptotic cells were measured by TUNEL assay.RESULTS:By LSCM,it was found that the intracellular calcium was significantly increased during reperfusion both in A/R and activator group.Severe injury was found by HE staining in the above two groups,the number of apoptotic cells was significantly increased according to TUNEL assay.The expression of CaSR,caspase 3 and caspase 9 was significantly increased in A/R group and activator group compared with control.CONCLUSION:CaSR is involved in intracellular calcium overload in A/R cardiomyocyte,which can accelerate apoptosis during A/R.
ABSTRACT
OBJECTIVE To analyze problems of hospital infection monitoring and its strategies.METHODS Having investigated hospital infection cases during 2005 and statistically to analyze the data of infection monitoring.RESULTS Both of the missed report rate of hospital infection and the rate for detection of microbe samples were decreased.Antibiotics were misused.CONCLUSIONS Strengthening the training about hospital infection knowledge for increasing the rate for detection,strengthening the infection monitoring,checking the infection control strictly,and raising the antibiotics control policy and practice are important.